Introduction to utrogestan. Utrozhestan instructions for use, contraindications, side effects, reviews. The drug "Utrozhestan": side effects
Utrozhestan during pregnancy is prescribed as a hormonal drug, which acts as a synthetic analogue of progesterone, the main hormone secreted by women in position.
Hormone analogue vitamins Replacement
Reception pulls pain
contractions lying down
Distinctive feature this tool is a complete repetition of the chemical structure of the progesterone molecule. Since the natural hormone is not absorbed by the intestines, its synthetic analogue was created. It can be used topically, in suppositories, capsules and inside.
Indications for the use of the drug
From the moment of conception, the body must produce enough progesterone. First, the corpus luteum of the ovaries takes over this function, after that the placenta, but a certain level of progesterone is always needed. It is this hormone that prevents uterine contractions, and also provides normal development fetus. The proper course of labor and timely delivery also depend on progesterone.
Utrozhestan during pregnancy is prescribed:
- with a lack of progesterone, when there is a threat of termination of pregnancy;
- with the appearance of brown or bloody discharge;
- to restore hormonal levels;
- when planning a pregnancy;
- to prevent the threat of miscarriage.
In general, utrogestan during pregnancy is considered a kind of vitamin. It acts as a synthetic analogue of progesterone, while the effect on the body of the expectant mother is completely harmless.
Synthetic analogue of the hormone progesterone
The table shows the main reasons why utrogestan is prescribed during pregnancy:
Trimester | Reason for appointment | Contraindications |
The first | progesterone deficiency; risk of miscarriage; bloody issues. | thrombosis and thrombophlebitis; diabetes; bronchial asthma. |
Second | risk of miscarriage; strengthening the uterus; prevention of preterm birth. | thrombosis and thrombophlebitis; phlebeurysm; cardiovascular diseases; diabetes; bronchial asthma. |
Third | the threat of premature birth; strengthening of the uterus. | thrombosis and thrombophlebitis; phlebeurysm; cardiovascular diseases; diabetes; bronchial asthma. |
The composition of the drug and pharmacological action
Utrozhestan is an artificially created analogue of the hormone progesterone. As a rule, it is very difficult to completely compensate for the deficiency of this hormone during the bearing of a baby, since it does not enter the body from the outside and is not digested in the stomach.
Scientists were able to solve this problem by designing molecules of this hormone surrounded by peanut butter. This form is easier to digest and is not rejected by the body. The source of artificial progesterone during pregnancy is duphaston or, even better, utrogestan.
This drug can be called a kind of vitamin
The composition of the medicinal product includes:
- progesterone (natural or micronized);
- peanut butter;
- gelatin;
- soy lecithin;
- glycerol.
Since there are no substances that can react negatively with other drugs, utrogestan during pregnancy can be taken simultaneously with duphaston and other drugs prescribed by a doctor.
Deficiency and excess of progesterone at all stages of bearing a child threatens expectant mother various consequences. That is why taking utrozhestan suppositories during pregnancy in the first or third trimester are two different things.
In the first trimester, unlike the third, excessive activity of the uterus is not so dangerous, because it cannot affect labor activity. It is much more dangerous if the egg, and then the small fetus, is rejected by the body. Moreover, it is this time that is characterized by a redistribution of functions between the placenta and the ovary. Any violation at this stage is very dangerous. That is why doctors boldly prescribe duphaston or utrozhestan even when planning pregnancy for their patients.
For the same reasons, it is allowed to take Utrozhestan 200 suppositories during pregnancy in the second trimester, but it is better to avoid taking them in the third. The lack of a hormone is not such a danger, because it cannot provoke a miscarriage or premature birth. But taking a drug that affects the hormonal background can lead to negative consequences.
In the last trimester, an excess of the hormone is much more dangerous and less predictable than a deficiency. It is very difficult to control the level of progesterone while taking the drug.
Utrozhestan when planning pregnancy, penetrating into the body, does not act as a substitute for progesterone, but only supplements its level. Moreover, it stimulates protein lipase, increases fat accumulation. But it is worth noting that this is not the fat that all girls fear, but the one that acts as a source of energy and strength.
This drug increases the degree of glucose utilization, produces lactation, starts the work of the mammary glands, which is most important in the third trimester. Utrozhestan also helps to relax when planning pregnancy. nervous system, allows you to calm down and relax the body.
Consider the main advantages and disadvantages of taking this drug.
Instructions for use
According to the instructions for use, during pregnancy, utrogestan can be taken in 2 ways:
- capsules by mouth;
- candles - introvaginally.
The second method of using utrogestan during pregnancy is the most preferable and effective, as it has a minimum of side effects. However, the price of this drug is very impressive. Of course, just before the birth, when the stomach is already impressive, it is much more convenient to take pills, but the digestive system may not respond very well to this remedy.
Up to what period of pregnancy to take utrogestan and at what dosage - your doctor decides. The standard dose is 3 times / day for 2-3 weeks. However, the intake plan should be drawn up individually in accordance with the body of the expectant mother.
Cancellation of utrozhestan during pregnancy should be carried out in advance, since a sudden stop can provoke a miscarriage: the level of progesterone will drop sharply. Therefore, your doctor should tell you how to cancel utrogestan during pregnancy.
As a rule, the dose is reduced gradually every 1-2 weeks. Thus, the duration of drug withdrawal can be from 3 to 7 weeks.
Although this drug does not include so many components, it is still a medicine. Therefore, among the contraindications for use, we can distinguish:
- thrombophlebitis, thrombosis;
- the presence of malignant tumors or past diseases of the reproductive system, mammary glands and uterus;
- spontaneous bleeding or discharge from the genitals;
- violations of the liver, liver failure;
- phlebeurysm;
- diseases of the heart and blood vessels;
- diabetes;
- bronchial asthma;
- the presence of diseases of the nervous system in history.
The specialist should observe you during the entire period of taking this remedy. This is especially true for the third trimester, when any change can lead to premature birth. See your doctor more often to prevent problems before they occur.
Consult your doctor about dosage
As for side effects, this drug has few of them. The main ones are:
- drowsiness;
- dizziness;
- distraction, so you should not take this remedy before going out;
- liver disease - can develop if you take this remedy in the last trimester of pregnancy;
- an excess of progesterone, which can lead to indigestion, is dangerous because the child will not receive enough energy and will not be able to grow well.
Reception when planning conception
Utrozhestan when planning pregnancy can be prescribed in several cases:
- Infertility caused by a lack of progesterone.
- If a miscarriage has previously occurred, the cause of which was a hormonal failure in the direction of reducing the main hormone of pregnancy.
- There is an asymptomatic decrease in the concentration of progesterone in the blood.
To conduct a laboratory test, which must be carried out to confirm the need for taking the drug, great importance plays the day of menstruation. One of the characteristics of progesterone, as a natural hormone, is its volatility, so the study should be carried out in the second phase of the cycle.
Is it dangerous.
Progesterone deficiency is a fairly common phenomenon that poses a serious danger both to conception and to bearing a baby. The need to take progesterone in the form of a medicine also continues during the onset of pregnancy in order to avoid its interruption. That is why utrozhestan is so often prescribed when planning conception, as well as during the first weeks of bearing a child.
Patients' opinion
Consider what women who already have experience with taking utrogestan during pregnancy think and have left their reviews about this drug.
Ekaterina Kozlovskaya:
I couldn't get pregnant for a long time. After a year of futile attempts, I went to the gynecologist, passed a bunch of tests, and I was diagnosed with progesterone deficiency. The doctor prescribed a course of treatment with utrogestan. I drank strictly according to the indicated scheme for a month, after which I saw the cherished two stripes on the test. The doctor said to continue taking it until 20 weeks, so as not to provoke a miscarriage. At the same time, I also drank vitamins Elevit. The doctor also prescribed the cancellation of the drug for me - it is very confusing, so never try to stop taking it yourself so as not to harm your baby. In general, the drug is good. The only negative is that I wanted to sleep all the time, but maybe it was just the pregnancy that had an effect.
Galina Shishkova:
At the 5th week of pregnancy, spotting appeared. I was very scared and immediately ran to the doctor. I was examined and diagnosed with a lack of progesterone. The doctor prescribed to put candles utrozhestan during pregnancy. I immediately looked at the reviews on the Internet - there were a lot of positive ones. With a calm soul, I started taking it, and after a week everything was gone. I canceled the drug for almost 4 weeks according to a special scheme. The drug is good, but I do not advise anyone to take it on their own, since an overdose of the hormone is fraught with serious consequences.
Marina Devyatova:
I was prescribed utrozhestan when planning a pregnancy. I heard a lot of reviews about this drug before, but they were all ambiguous. Since I really wanted a baby, I trusted the doctor and did everything as I was told. After 4 months of taking the drug, I managed to get pregnant, but I drank it before 16 weeks. Then another 6 weeks was cancelled. In general, the drug is very serious, I don’t think that I will ever take it without a doctor’s prescription.
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The information published on the site is for informational purposes only and is intended for informational purposes only. Site visitors should not use them as medical advice! The editors of the site do not recommend self-medication. Determining the diagnosis and choosing a treatment method remains the exclusive prerogative of your doctor! Remember that only a complete diagnosis and therapy under the supervision of a doctor will help to completely get rid of the disease!
Quite often, women have to use a variety of hormonal agents. Among them are oral contraceptives and drugs that help get pregnant. In this article we will talk about a drug called "Utrozhestan". and instructions for using the product will be described below. You will find out what is the peculiarity of taking this hormonal medication and who needs it. It is also worth saying what analogues the drug has.
The composition of the drug and its form of release
The main active ingredient of the drug is progesterone. It is presented in microdosed form. In addition, the capsules contain peanut butter, glycerol, gelatin and
Consumers are presented with two forms of release of this medicine: "Utrozhestan 200" and "Utrozhestan 100". They differ from each other only in dosage. This is provided for ease of use of the drug.
Who needs the drug?
This remedy should only be prescribed by a specialist. In this case, an individual dose of the drug is always selected. Most often, the drug is used in the following cases:
- to normalize the menstrual cycle;
- with endometriosis;
- during the growth of functional cysts;
- to maintain pregnancy;
- with some diseases of the mammary gland;
- for the treatment of infertility of hormonal origin;
- with exacerbation of premenstrual syndrome;
- as hormone replacement therapy;
- for the prevention and treatment of hormonal diseases and so on.
Are there any contraindications for taking pills?
Like many other drugs, the drug "Utrozhestan" 200 and 100 can not be used with hypersensitivity to the components. So, if you are allergic to peanut butter or soy, you should choose an alternative remedy for treatment.
When it is still impossible to use Utrozhestan tablets? Instructions for use says the following. Capsules are contraindicated in thrombosis of veins and arteries. Also, during an exacerbation of phlebitis, you should not take this medicine. It is strictly forbidden to use the hormone for incomplete abortion or bleeding from the genital organs of unknown origin. You can not drink capsules with kidney and liver failure, in case of detection of malignant tumors that are hormonally dependent.
With extreme caution, it is worth using the remedy for problems with blood vessels and the heart, during lactation, and so on. Before taking it, you should definitely consult with a specialist and undergo some examinations.
At what dose and how to use the remedy?
Can be used in different forms and doses of the drug "Utrozhestan". Instructions for use speaks of the following schemes for taking the drug.
For oral use
The daily dose of the drug is from 200 to 400 milligrams. In this case, the capsules should be washed down with a large amount of liquid (it is better to use plain water).
With a lack of progesterone in the body, use 1-2 capsules of 200 milligrams or 2-4 tablets of 100 milligrams per day. The portion is divided into two doses. In this case, the interval between the use of the drug should be 12 hours.
If the correction of insufficiency of pronounced premenstrual syndrome and other pathologies is carried out, then the drug is prescribed after ovulation. Most often, the following scheme is chosen: from 200 to 400 milligrams of progesterone are taken per day. The course of treatment lasts from the 17th to the 26th day of the menstrual cycle. However, in some cases, a different interval may be selected.
For vaginal administration
Reception "Utrozhestan" is often non-oral. In this case, the drug is injected deep into the vagina. Most often, this method is chosen in the following cases: in preparation for artificial insemination, for replacement during pregnancy and in case of a threat of its interruption.
Vaginal administration of the drug is allowed at a dose of 200 to 600 milligrams daily. Most often, the remedy is used twice a day: in the morning and in the evening. When threatened, the drug should be administered at regular intervals. If severe bleeding occurs, then it makes sense to replace the drug with an alternative one or use additional drugs containing progesterone.
The drug "Utrozhestan" application in this case has the following: wash your hands thoroughly with soap and water. The introduction of capsules with dirty hands can lead to infection of the genital tract. After that, open the capsule and take it with two fingers. Squat down and inject the drug deep into the vagina. After using the product, it is recommended to spend some time at rest.
How does the medicine work?
After using the drug, the immediate absorption of the active substance into the blood begins. When taken orally, the remedy gives an effect after 3-4 hours. If the vaginal method of administration is used, the capsules begin to act after 1-2 hours.
The agent is actively distributed throughout the body and has an effect mainly on smooth muscles. So, progesterone helps the endometrium to move from one phase to another. When pregnancy occurs, Utrozhestan tablets support the normal production of progesterone and help to relax the reproductive organ. If there is a threat of abortion, then the drug removes the tone from the uterus and stops bleeding, which is caused by a lack of hormone.
The drug is excreted mainly in the urine after 12-16 hours. That is why, if it is necessary to maintain the level of progesterone, you need to use the remedy at regular intervals.
The drug "Utrozhestan": side effects
Like any other medicine, this remedy can cause negative reactions in the body. It is worth noting that most often this happens with the independent use of the drug without a doctor's prescription. Also, the tool causes an unexpected reaction of the body with an overdose or a reduction in the time between doses of portions. The drug "Utrozhestan" side effects may have the following.
Allergy
If there is intolerance to any component of the drug, then this is manifested by a skin rash, itching, redness of the genital organs (with vaginal administration). Nausea and vomiting may also occur. All these symptoms should be treated with appropriate drugs. The hormonal medicine should be replaced with a similar one in action.
Change in the work of the excretory organs
When used orally, the drug "Utrozhestan" has side effects in the form of increased and thinning of the stool. Some patients report constipation and bloating. This may be due to the influence of the agent on smooth muscles.
In addition, the drug can cause a diuretic effect on the body. Especially often this occurs with the use of appropriate drugs. Most often, treatment for such effects is not required, and therapy is not canceled.
The reaction of the nervous system
Side effects of the drug can be headache, weakness and drowsiness. Most often, these symptoms appear within 1-3 hours after ingestion. Doctors advise in this case to cancel the treatment with "Utrozhestan" and choose an alternative drug.
Bleeding from the genital tract
Very rarely, the drug may be accompanied by spotting spotting. It is necessary to report this side effect your doctor and change your treatment regimen if necessary.
Price category of the drug
The cost of the drug depends on the dosage in which it is released. You can purchase 30 capsules of 100 milligrams for about 400 rubles. If you need a large dosage, then the price will be appropriate. The average cost of 14 tablets of 200 milligrams is in the range of 500 to 600 rubles.
Drug analogues
The medicine "Utrozhestan" when planning pregnancy is often replaced by analogues. This is most often due to ease of use and intolerance of some components. Among similar funds, the following can be distinguished: Prajisan, Progestogel, Progesterone, Iprozhin and Dufaston. All of these drugs may different way use. Some are for oral use only, while others are administered intravenously or vaginally.
Many patients ask their doctor: “Which is better, Duphaston or Utrozhestan?” In fact, the effect of these funds is the same. The only difference is that Duphaston contains synthetic progesterone and can only be used orally.
Conclusion
So you know all about hormonal preparation called "Utrozhestan". Remember that you can use it only after consulting a specialist. What is better - "Dufaston" or "Utrozhestan" in your case - the doctor will decide. Health to you!
KNF (drug is included in the Kazakhstan National Formulary medicines)
Manufacturer: OLIK (Thailand) Limited
Anatomical-therapeutic-chemical classification: Progesterone
Registration number: No. RK-LS-5 No. 015741
Date of registration: 29.12.2014 - 29.12.2019
Limit price: 136.57 KZT
Instruction
- Russian
Tradename
Utrozhestan®
International non-proprietary name
Progesterone
Dosage form
Capsules 100 mg, 200 mg
Compound
1 capsule contains
activeohsubstancesabout - progesterone natural micronized 100 mg or 200 mg
Excipients: soy lecithin, sunflower oil,
composition of the capsule shell: gelatin, glycerin, titanium dioxide (E 171)
Description
Round soft, shiny yellowish gelatin capsules containing an oily whitish homogeneous suspension (no visible phase separation) (for a dosage of 100 mg).
Oval soft, glossy yellowish gelatin capsules containing an oily whitish homogeneous suspension (no visible phase separation) (for a dosage of 200 mg).
Pharmacotherapeutic group
Sex hormones and modulators of the reproductive system. Progestogens. Pregnene derivatives. Progesterone.
ATX code G03DA04
Pharmacological properties
Pharmacokinetics
When taken orally
Micronized progesterone is absorbed from the gastrointestinal tract. The concentration of progesterone in the blood plasma gradually increases during the first hour, the maximum concentration in the blood (Cmax) is observed 1-3 hours after ingestion. Communication with plasma proteins - 90%.
The concentration of progesterone in blood plasma increases from 0.13 ng/ml to 4.25 ng/ml after 1 hour, up to 11.75 ng/ml after 2 hours and is 8.37 ng/ml after 3 hours, 2 ng/ml after 6 hours and 1.64 ng/ml after 8 hours.
The main metabolites that are determined in the blood plasma are 20-alpha-hydroxy-delta-4-alpha-pregnanolone and 5-alpha-dihydroprogesterone.
Excreted in the urine as metabolites, 95% of which are glucuron-conjugated metabolites, mainly 3-alpha, 5-beta-pregnandiol (pregnandione)
The indicated metabolites, which are determined in the blood plasma and in the urine, are similar to the substances formed during the physiological secretion of the corpus luteum.
When administered vaginally
Absorption occurs quickly, progesterone accumulates in the uterus, high level plasma progesterone is observed 1 hour after administration. Cmax of progesterone in plasma is achieved 2-6 hours after administration. With the introduction of the drug at 100 mg 2 times / day, the average concentration remains at the level of 9.7 ng / ml for 24 hours.
When administered in doses of more than 200 mg / day, the concentration of progesterone corresponds to the 1st trimester of pregnancy. Communication with plasma proteins - 90%.
It is metabolized with the formation of predominantly 3-alpha, 5-beta-pregnandiol. The level of 5-beta-pregnanolone in plasma does not increase.
It is excreted in the urine as metabolites, the main part is 3-alpha, 5-beta-pregnandiol (pregnandione). This is confirmed by a constant increase in its concentration (Cmax 142 ng / ml after 6 hours).
Pharmacodynamics
Progestogen, corpus luteum hormone. By binding to receptors on the surface of cells of target organs, it penetrates into the nucleus, where, by activating DNA, it stimulates RNA synthesis. It promotes the transition of the uterine mucosa from the proliferation phase caused by the follicular hormone to the secretory phase, and after fertilization to the state necessary for the development of a fertilized egg. Reduces the excitability and contractility of the muscles of the uterus and fallopian tubes, stimulates the development of the terminal elements of the mammary gland.
By stimulating protein lipase, increases fat stores, increases glucose utilization, increases the concentration of basal and stimulated insulin, promotes the accumulation of glycogen in the liver, increases the production of gonadotropic hormones pituitary gland; reduces azotemia, increases the excretion of nitrogen in the urine. Activates the growth of the secretory part of the acini of the mammary glands and induces lactation. Promotes the formation of normal endometrium.
Indications for use
Progesterone deficiency states.
Oral route of administration
Gynecological:
Progesterone deficiency disorders:
Premenstrual syndrome
Irregular menstrual cycles with dysovulation or anovulation
Benign mastopathy
premenopause
Menopause therapy (in addition to estrogen therapy)
Infertility due to luteal insufficiency.
Obstetrics:
Threatened miscarriage or prevention of habitual miscarriages due to established luteal insufficiency
Threat of preterm birth
ATaginal route of administration
Hypofertility, primary or secondary infertility associated with partial or total luteal insufficiency (dysovulation, support of the luteal phase during in vitro fertilization, oocyte donation)
The threat of early miscarriage or the prevention of habitual abortions associated with luteal insufficiency
Dosage and administration
The duration of treatment is determined by the nature and characteristics of the disease.
Oral route of administration
On average, the dose is 200-300 mg of progesterone per day, divided into 1 or 2 doses, i.e. 200 mg in the evening at bedtime and 100 mg in the morning as needed.
Atluteal insufficiency (premenstrual syndrome, menstrual disorders, premenopause, benign mastopathy): treatment should be carried out for 10 days per cycle, usually from the 17th to the 26th day inclusive.
Atmenopause therapy: Because estrogen therapy alone is not recommended, progesterone is added in the last two weeks of each therapeutic course, followed by the discontinuation of any replacement treatment for about one week, during which abstinence bleeding may occur.
Atrisk of preterm birth: 400 mg of progesterone every 6-8 hours depending on clinical results obtained during the acute phase, then at a maintenance dosage (eg, 3 times 200 mg per day) until the 36th week of pregnancy.
Vaginal route of administration
The average dose is 200 mg of progesterone per day (i.e. 1 capsule of 200 mg or two capsules of 100 mg divided into 2 doses, 1 in the morning and 1 in the evening), which is injected deep into the vagina, if necessary with the help of an applicator. The dose may be increased depending on the response of the patient.
Atpartial luteal insufficiency(dysovulation, menstrual disorders): treatment should be carried out for 10 days per cycle, usually from the 17th to the 26th day at the rate of 200 mg of progesterone per day.
Atinfertility with complete luteal phase deficiency (oocyte donation): the progesterone dose is 100 mg progesterone on days 13 and 14 of the transfer cycle, then 100 mg progesterone in the morning and evening from days 15 to 25 of the cycle. In the case of the initial stage of pregnancy, starting from the 26th day, the dose is increased from 100 mg of progesterone per day to a maximum of 600 mg of progesterone per day, divided into three doses. This dosage should be observed until the 60th day.
With the support ofluteal phase during in vitro fertilization treatment should be carried out starting from the evening of the transfer day, at the rate of 600 mg of progesterone in three doses - in the morning, afternoon and evening.
With the threat of a miscarriage or with the prevention of a habitual miscarriage due to luteal insufficiency
the average dosage is 200-400 mg of progesterone per day in two doses until the 12th week of pregnancy.
The capsule must be inserted deep into the vagina.
Side effects:
The following adverse events have been reported with oral administration:
Often>l/100;<1/10 :
Menstrual irregularity
Amenorrhea
Intermenstrual bleeding
Headache
Infrequently>l/1000;<1/100:
Mammalgia
Drowsiness
Transient feeling of dizziness
cholestatic jaundice
Rare >l/10000;<1/1000:
Nausea
Very rarely<1/10000:
Depression
Hives
Chloasma
For vaginal use:
Despite the possibility of local irritation (soy lecithin), no local intolerance (burning, itching or greasy discharge) was observed in various clinical studies.
Contraindications
Hypersensitivity to the active or auxiliary components of the drug
Tendency to thrombosis, acute forms of phlebitis or thromboembolic diseases
Bleeding from the genital tract of unknown origin
Abortion incomplete
Porfiria
Established or suspected malignant neoplasms of the mammary glands and genital organs
Severe liver dysfunction
FROMcaution
Diseases of the cardiovascular system
Arterial hypertension
Chronic renal failure
Diabetes
Bronchial asthma
Epilepsy
Migraine
Depression
Hyperlipoproteinemia
lactation period
Drug Interactions
With hormonal therapy of menopause with estrogen, it is necessary to prescribe progesterone for at least 12 days per cycle.
Combined use with other drugs may cause an increase in progesterone metabolism and a change in the action of the drug.
This happens in cases where:
Liver enzyme inducers such as barbiturates, antiepileptic drugs (phenytoin), rifampicin, phenylbutazone, spironolactone, and griseofulvin (these drugs cause increased metabolism at the liver level)
Some antibiotics (ampicillins, tetracyclines) cause changes in the intestinal microflora, the consequence of which is a change in the enterohepatic steroid cycle.
Progestogens can cause a decrease in glucose tolerance, therefore it is necessary to increase the need for insulin or other antidiabetic drugs in a diabetic patient.
The bioavailability of progesterone can be reduced in patients who smoke and with excessive alcohol consumption.
special instructions
IS NOT A CONTRACENTIVE.
Treatment should be carried out in accordance with existing recommendations.
If the course of treatment is started too early at the beginning of the monthly cycle, especially before the 15th day of the cycle, shortening of the cycle or bleeding may occur.
In case of uterine bleeding, the drug should not be prescribed until their cause is clarified (for example, examination of the uterine cavity).
Due to thromboembolic and metabolic risks, which cannot be completely ruled out, it should be discontinued if:
Visual disturbances (such as vision loss, double vision, retinal vascular lesions)
Thromboembolic venous or thrombotic complications (regardless of their location)
Severe headaches.
With a thrombophlebic history, the patient should be closely monitored.
If amenorrhea occurs during treatment, it is necessary to make sure that we are not talking about pregnancy.
More than 50% of early spontaneous abortions are caused by genetic complications. The appointment of progesterone on the recommendation of a doctor is indicated in case of insufficient secretion of the corpus luteum.
Utrogestan contains soy lecithin and may cause hypersensitivity reactions (urticaria and anaphylactic shock).
Pregnancy and lactation
The use of UTROZHESTAN vaginal route of administration, capsules is not contraindicated during pregnancy, including in the first weeks. (see section: "Indications for use."
The passage of progesterone into breast milk has not been adequately studied. Therefore, its administration should be avoided during breastfeeding.
Features of the influence of the drug on the ability to drive a vehicle or potentially dangerous mechanisms
The attention of drivers of vehicles and persons working with mechanisms should be drawn to the risk of drowsiness and / or dizziness associated with the use of this drug orally. Taking the capsules at bedtime avoids these side effects.
Care should be taken when driving vehicles and engaging in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.
Overdose
Symptoms: an increase in side effects indicates an overdose.
They spontaneously disappear with a decrease in the dose of the drug.
In some patients with a history of unstable endogenous secretion, the usual dose of progesterone may be excessive and result in extreme drug sensitivity or too low concomitant estradiolemia.
Treatment: dose reduction or administration of progesterone EVENING BEFORE SLEEP for ten days. In case of drowsiness or transient feeling of dizziness, it is necessary to postpone the start of treatment to a later date in the cycle (for example, the 19th day instead of the 17th). In case of cycle shortening or spotting, it is necessary to check that estradiolemia is sufficient in premenopause and in menopausal hormone replacement therapy.
Release form
14 capsules in a blister pack made of PVC / aluminum foil or PVC / PVDC / aluminum foil.
2 blisters, together with instructions for medical use in the state and Russian languages, are put into a pack of cardboard (for a dosage of 100 mg).
7 capsules in a blister pack made of PVC / aluminum foil or PVC / PVDC / aluminum foil.
Utrozhestan - progestogen, the active substance of which is progesterone, identical to the natural hormone of the corpus luteum of the ovary. By binding to receptors on the surface of cells of target organs, it penetrates into the nucleus, where, by activating DNA, it stimulates RNA synthesis. Promotes the transition of the uterine mucosa from the proliferation phase caused by the follicular hormone estradiol to the secretory phase, and after fertilization to the state necessary for the development of a fertilized egg.
Reduces the excitability and contractility of the muscles of the uterus and fallopian tubes.
Promotes the formation of normal endometrium. Stimulates the development of the terminal elements of the mammary gland and induces lactation.
By stimulating protein lipase, it increases fat reserves; increases the utilization of glucose; increasing the concentration of basal and stimulated insulin, promotes the accumulation of glycogen in the liver; increases the production of gonadotropic hormones of the pituitary gland; reduces azotemia, increases the excretion of nitrogen by the kidneys.
Pharmacokinetics
When taken orally. SuctionMicronized progesterone is well absorbed from the gastrointestinal tract (GIT). The concentration of progesterone in the blood plasma gradually increases during the first hour, the maximum concentration in the blood plasma (C max) is observed 1-3 hours after ingestion. The concentration of progesterone in the blood plasma increases from 0.13 ng / ml to 4.25 ng / ml after 1 hour, to 11.75 ng / ml after 2 hours and is 8.37 ng / ml after 3 hours, 2 ng / ml 6 hours later and 1.64 ng/ml 8 hours after ingestion.
Metabolism. The main metabolites that are determined in the blood plasma are 20-alpha-hydroxy-delta-4-alpha-pregnanolone and 5-alpha-dihydroprogesterone.
Withdrawal. It is excreted by the kidneys as metabolites, 95% of which are glucuron-conjugated metabolites, mainly 3-alpha, 5-beta-pregnandiol (pregnandione). These metabolites, which are determined in blood plasma and urine, are similar to substances formed during the physiological secretion of the corpus luteum.
When administered vaginally
absorption and distribution. Absorption occurs quickly, a high concentration of progesterone in the blood plasma is observed 1 hour after administration. Cmax of progesterone in blood plasma is achieved 2-6 hours after administration. With the introduction of 100 mg 2 times a day, the average concentration in blood plasma remains at the level of 9.7 ng / ml for 24 hours. When administered in doses of more than 200 mg / day, the concentration of progesterone corresponds to the first trimester of pregnancy. Communication with plasma proteins - 90%. Progesterone accumulates in the uterus.
Metabolism. It is metabolized with the formation of predominantly 3-alpha, 5-beta-pregnandiol.
The concentration of 5-beta-pregnanolone in the blood plasma does not increase.
Withdrawal. It is excreted by the kidneys in the form of metabolites, the main part is 3-alpha, 5-beta-pregnandiol (pregnandione). This is confirmed by a constant increase in its concentration (Cmax 142 ng/ml after 6 hours).
Indications for use
Utrozhestan used for progesterone deficiency conditions in women:For oral administration: threatening abortion or prevention of habitual abortion due to progesterone deficiency; infertility due to luteal insufficiency; premenstrual syndrome; menstrual disorders due to ovulation or anovulation disorders; fibrocystic mastopathy; period of menopausal transition; menopausal (replacement) hormone therapy (MHT) in peri- and postmenopause (in combination with estrogen-containing drugs).
Utrozhestan for intravaginal use: MHT in case of progesterone deficiency with non-functioning (absent) ovaries (egg donation); prevention (prevention) of preterm birth in women at risk (with shortening of the cervix and / or the presence of anamnestic data of preterm birth and / or premature rupture of the membranes); support of the luteal phase during preparation for in vitro and fertilization; support of the luteal phase in a spontaneous or induced menstrual cycle; premature menopause; MHT (in combination with estrogen-containing drugs); infertility due to luteal insufficiency; threatened abortion or prevention of habitual abortion due to progesterone deficiency.
Mode of application
Orally. A drug Utrozhestan taken orally in the evening before bedtime, drinking water.In most cases, with progesterone deficiency, the daily dose of Utrozhestan is 200-300 mg, divided into 2 doses (200 mg in the evening before bedtime and 100 mg in the morning, if necessary).
With threatened abortion or to prevent habitual abortion due to progesterone deficiency: 200-600 mg per day daily in the first and second trimesters of pregnancy.
Further use of the drug Utrozhestan is possible according to the prescription of the attending physician based on an assessment of the clinical data of the pregnant woman.
women.
In case of insufficiency of the luteal phase (premenstrual syndrome, fibrocystic mastopathy, dysmenorrhea, menopausal transition period), the daily dose is 200 or 400 mg taken for 10 days (usually from the 17th to the 26th day of the cycle).
With MHT in perimenopause while taking estrogens, the drug Utrozhestan is used at 200 mg per day for 12 days.
With MHT in postmenopausal women in continuous mode, the drug Utrozhestan is used at a dose of 100-200 mg from the first day of taking estrogen-containing drugs.
Dose selection is carried out individually.
Intravaginally. Capsules Utrozhestan injected deep into the vagina.
Prevention (prevention) of preterm labor in women at risk (with a short cervix and/or a history of preterm labor and/or preterm rupture of membranes): the usual dose is 200 mg at bedtime, from the 22nd to the 34th week pregnancy.
Complete absence of progesterone in women with non-functioning (absent) ovaries (egg donation): against the background of estrogen therapy, 100 mg per day on the 13th and 14th days of the cycle, then 100 mg 2 times a day from the 15th to the 25th day of the cycle, from the 26th day, and in case of pregnancy, the dose increases by 100 mg per day every week, reaching a maximum of 600 mg per day, divided into 3 doses.
The specified dose can be used for 60 days.
Support of the luteal phase during the in vitro fertilization cycle: it is recommended to use from 200 to 600 mg per day, starting from the day of the injection of human chorionic gonadotropin during the first and second trimesters of pregnancy.
Support of the luteal phase in a spontaneous or induced menstrual cycle in case of infertility associated with impaired function of the corpus luteum: it is recommended to use 200-300 mg per day, starting from the 17th day of the cycle for 10 days, in case of delayed menstruation and diagnosis of pregnancy, treatment should be continued.
In cases of threatened abortion or in order to prevent habitual abortion that occurs against the background of progesterone deficiency: 200-400 mg per day in 2 doses daily in the I and II trimesters of pregnancy.
Side effects
The following adverse events noted with the oral route of administration of the drug Utrozhestan.Violations of the genital organs and mammary gland: menstrual disorders, amenorrhea, acyclic bleeding, mastodynia.
Psychiatric disorders: depression.
Nervous system disorders: headache, drowsiness, transient dizziness.
Gastrointestinal disorders: bloating, vomiting, diarrhea, constipation, nausea.
Liver and biliary tract disorders: cholestatic jaundice.
Immune system disorders: urticaria.
Skin and subcutaneous tissue disorders: itching, acne, chloasma.
Drowsiness, transient dizziness are possible, as a rule, 1-3 hours after oral administration of the drug. These adverse reactions can be reduced by reducing the dose, using the drug at bedtime, or switching to the vaginal route of administration.
These adverse reactions are usually the first signs of an overdose.
Drowsiness and / or transient dizziness are observed, in particular, in the case of concomitant hypoestrogenism. Reducing the dose or restoring higher estrogen levels immediately reverses these effects without reducing the therapeutic effect of progesterone.
If the course of treatment is started too early (in the first half of the menstrual cycle, especially before the 15th day), shortening of the menstrual cycle or acyclic bleeding is possible.
Recorded changes in the menstrual cycle, amenorrhea or acyclic bleeding are characteristic of all gestagens.
Application in clinical practice
When used in clinical practice, the following adverse events have been noted with oral progesterone: insomnia; premenstrual syndrome; tension in the mammary glands; vaginal discharge; pain in the joints; hyperthermia; increased sweating at night; fluid retention; change in body weight; acute pancreatitis; alopecia, hirsutism; libido changes; thrombosis and thromboembolic complications (during MHT in combination with estrogen-containing drugs); increase in blood pressure.
The composition of the drug includes soy lecithin, which can cause hypersensitivity reactions (urticaria and anaphylactic shock).
When used vaginally
It was reported about individual cases of the development of reactions of local intolerance to the components of the drug (in particular, soy lecithin) in the form of hyperemia of the vaginal mucosa, burning, itching, oily discharge.
Systemic side effects with intravaginal use of the drug at recommended doses, in particular, drowsiness or dizziness (observed with oral administration of the drug), were not observed.
Contraindications
Contraindications to the use of the drug Utrozhestan are: hypersensitivity to progesterone or any of the excipients of the drug; deep vein thrombosis, thrombophlebitis; thromboembolic disorders (pulmonary embolism, myocardial infarction, stroke), intracranial hemorrhage or a history of these conditions / diseases; bleeding from the vagina of unknown origin; incomplete abortion; porphyria; established or suspected malignant neoplasms of the breast and genital organs; severe liver disease (including cholestatic jaundice, hepatitis, Dubin-Johnson syndrome, Rotor syndrome, malignant liver tumors) at present or in history; children under 18 years of age (efficacy and safety have not been established); period of breastfeeding.With caution: diseases of the cardiovascular system, arterial hypertension, chronic renal failure, diabetes mellitus, bronchial asthma, epilepsy, migraine, depression, hyperlipoproteinemia, mild to moderate liver dysfunction; photosensitivity.
The drug should be used with caution in the II and III trimesters of pregnancy.
Pregnancy
A drug Utrozhestan should be used with caution in the II and III trimesters of pregnancy due to the risk of developing cholestasis.Progesterone passes into breast milk, so the use of the drug is contraindicated during breastfeeding.
Interaction with other drugs
When administered orally Utrozhestan.Progesterone enhances the effect of diuretics, antihypertensive drugs, immunosuppressants, anticoagulants. Reduces the lactogenic effect of oxytocin.
Simultaneous use with drugs-inducers of microsomal liver enzymes CYP3A4, such as barbiturates, antiepileptic drugs (phenytoin, carbamazepine), rifampicin, phenylbutazone, spironolactone, griseofulvin, is accompanied by an acceleration of progesterone metabolism in the liver.
Simultaneous administration of progesterone with certain antibiotics (penicillins, tetracyclines) can lead to a decrease in its effectiveness due to a violation of the enterohepatic recirculation of sex hormones due to changes in the intestinal microflora.
The severity of these interactions may vary in different patients, so the prediction of the clinical effects of these interactions is difficult.
Ketoconazole may increase the bioavailability of progesterone.
Progesterone can increase the concentration of ketoconazole and cyclosporine.
Progesterone may reduce the effectiveness of bromocriptine.
Progesterone can cause a decrease in glucose tolerance, resulting in an increase in the need for insulin or other hypoglycemic drugs in patients with diabetes mellitus.
The bioavailability of progesterone can be reduced in patients who smoke and with excessive alcohol consumption.
For intravaginal use
The interaction of progesterone with other drugs for intravaginal use has not been evaluated. The simultaneous use of other drugs used intravaginally should be avoided in order to avoid impaired release and absorption of progesterone.
Overdose:
Symptoms of drug overdose Utrozhestan: drowsiness, transient dizziness, euphoria, shortening of the menstrual cycle, dysmenorrhea.
In some patients, the average therapeutic dose may be excessive due to existing or emerging unstable endogenous secretion of progesterone, special sensitivity to the drug, or too low a concentration of estradiol.
Treatment: in case of drowsiness or dizziness, it is necessary to reduce the daily dose or prescribe the drug at bedtime for 10 days of the menstrual cycle; in case of shortening of the menstrual cycle or “spotting” spotting, it is recommended to postpone the start of treatment to a later day of the cycle (for example, on the 19th instead of the 17th); in perimenopause and with MHT in postmenopause, it is necessary to make sure that the concentration of estradiol is optimal.
In case of overdose, if necessary, symptomatic treatment is carried out.
Storage conditions
Store at a temperature not exceeding 25 °C.Keep out of the reach of children.
Release form
Capsules 100 mg. 14 capsules in a PVC / aluminum foil or PVC / PVDC / aluminum foil blister. 2 blisters with instructions for use in a cardboard box (28 capsules in consumer packaging).Capsules 200 mg. 7 capsules in a PVC / aluminum foil or PVC / PVDC / aluminum foil blister. 2 blisters with instructions for use in a cardboard box (14 capsules in consumer packaging).
Compound
:1 capsule Utrozhestan contains the active ingredient: micronized progesterone 100 or 200 mg.
Excipients: sunflower oil 149 mg/298 mg, soy lecithin 1 mg/2 mg; capsule - gelatin 76.88 mg / 153.76 mg, glycerin 31.45 mg / 62.9 mg, titanium dioxide 1.67 mg / 3.34 mg.
Description: 100 mg capsules are round, 200 mg capsules are oval, soft, shiny yellowish gelatin capsules containing an oily whitish homogeneous suspension (no visible phase separation).
Additionally
A drug Utrozhestan should not be used for contraception.The drug should not be taken with food, as food intake increases the bioavailability of progesterone.
The drug Utrozhestan should be taken with caution in patients with diseases and conditions that may be aggravated by fluid retention (arterial hypertension, cardiovascular disease, chronic renal failure, epilepsy, migraine, bronchial asthma); in patients with diabetes; impaired liver function of mild and moderate severity; photosensitivity.
Patients with a history of depression should be observed, and if severe depression develops, the drug should be discontinued.
The composition of the drug Utrozhestan includes soy lecithin, which can cause hypersensitivity reactions (urticaria and anaphylactic shock).
Patients with concomitant cardiovascular diseases or their history should also be periodically observed by a doctor.
The use of the drug Utrozhestan after the first trimester of pregnancy can cause the development of cholestasis.
With prolonged treatment with progesterone, regular medical examinations (including a study of liver function) should be carried out; treatment should be discontinued in the event of abnormal liver function tests or cholestatic jaundice.
When using progesterone, it is possible to reduce glucose tolerance and increase the need for insulin and other hypoglycemic drugs in patients with diabetes mellitus.
In the event of amenorrhea during treatment, it is necessary to exclude the presence of pregnancy.
If the course of treatment is started too early at the beginning of the menstrual cycle, especially before the 15th day of the cycle, shortening of the cycle and / or acyclic bleeding is possible. In the case of acyclic bleeding, the drug should not be used until their cause is clarified, including a histological examination of the endometrium.
Patients with a history of chloasma or a tendency to develop it are advised to avoid UV exposure.
More than 50% of cases of spontaneous abortions in early pregnancy are due to genetic disorders. In addition, the cause of spontaneous abortions in early pregnancy can be infectious processes and mechanical damage. The use of the drug Utrozhestan in these cases can only lead to a delay in rejection and evacuation of a non-viable fetal egg.
The use of the drug Utrozhestan in order to prevent a threatened abortion is justified only in cases of progesterone deficiency.
When conducting MHT with estrogens during the perimenopausal period, it is recommended to use the drug Utrozhestan for at least 12 days of the menstrual cycle.
With a continuous regimen of MHT in postmenopausal women, it is recommended to use the drug from the first day of taking estrogens.
When conducting MHT, the risk of developing venous thromboembolism (deep vein thrombosis or pulmonary embolism), the risk of ischemic stroke, coronary heart disease increases.
Due to the risk of developing thromboembolic complications, the use of the drug should be discontinued in the event of: visual disturbances such as loss of vision, exophthalmos, double vision, vascular lesions of the retina; migraine; venous thromboembolism or thrombotic complications, regardless of their location.
If there is a history of thrombophlebitis, the patient should be closely monitored.
When using the drug Utrozhestan with estrogen-containing drugs, it is necessary to refer to the instructions for their use regarding the risks of venous thromboembolism.
The results of the Women Health Initiative Study (WHI) clinical study indicate a slight increase in the risk of breast cancer with long-term, more than 5 years, the combined use of estrogen-containing drugs with synthetic progestogens. It is not known whether there is an increased risk of breast cancer in postmenopausal women during MHT with estrogen-containing drugs in combination with progesterone.
The results of the WHI study also found an increased risk of dementia when starting MHT at age 65 or older.
Before starting MHT and regularly during it, a woman should be examined to identify contraindications to its implementation. If clinically indicated, a breast examination and gynecological examination should be performed.
The use of progesterone may affect the results of some laboratory tests, including indicators of liver function, thyroid gland; coagulation parameters; concentration of pregnandiol.
When using the drug orally, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require increased concentration of attention and speed of psychomotor reactions.
main parameters
Name: | UTROZHESTAN |
ATX code: | G03DA04 - |
The drug Utrozhestan (candles or tablets) contains a progestogenic sex hormone in its composition. You need a drug in order to become pregnant, as well as during pregnancy.
The active active element of this medication is the granulosa cells of the ovarian follicle, which produce an endogenous steroid. When it enters the body of a woman, it contributes to the normalization of secretory transformations in the uterine cavity.
Enhances the transformation of the mucosal layer, which promotes the formation and process of formation and growth of the embryo. During the period of gestation, it reduces the tone of the uterus, causes the end sections of the milk ducts in the chest to transform.
In the process of restoring the normal level of the biologically active form of testosterone, which blocks the production of pituitary gonadotropins, leads to a decrease in the level of androgens. Antimineralocorticoid action is manifested by increased urine output.
Compound
The composition of the drug Utrozhestan includes:
Release form and cost
The drug Utrozhestan is a candle and a pill at the same time. The drug is made in such a way that it can be used, if necessary, both vaginally and orally.
Produced in the form of dosed medicinal tablets of a rounded shape. They have a sparkling egg-colored surface. In the middle of the drug - a homogeneous ointment-like mixture of milky color. Tablet or candle: 0.1 g - 30 pcs. in a plate, 0.2 g each - 14 pcs. in the plate. The plate is placed in a container made of thick paper.
The cost of the drug Utrozhestan varies from 400 rubles. up to 500 rubles for 1 pack.
Taking the drug if pregnancy is only planned
Utrozhestan (during pregnancy at the planning stage) is used both orally and vaginally.
1. Orally:
- when it is impossible to conceive;
- in violation of the luteal phase;
- in the absence of ovulation;
- in violation of the release of the egg from the ovary into the fallopian tubes.
2. Vaginally:
Utrozhestan (during pregnancy or when planning it) has limitations and undesirable manifestations. The drug can only be prescribed by a doctor after an examination and determine whether there are contraindications or not.
Restrictions:
- chronic or acute stage of varicose veins of the lower extremities;
- thrombosis of the lower extremities;
- diseases of the biliary tract;
- hepatitis;
- malignant neoplasms;
- heart disease;
- encephalopathy;
- chronic inflammatory diseases of the respiratory system;
- with chronic insufficiency of the pancreatic hormone.
Undesirable manifestations:
- when administered orally, passivity, lethargy, drowsiness, unsteadiness of gait;
- decrease in the severity of the reaction;
- vegetative-vascular dystonia;
- astheno-neurotic syndrome.
Features of use during childbearing
During pregnancy, it is necessary to take the drug in the following situations:
- the threat of spontaneous abortion;
- as a prophylactic for the threat of abortion;
- inflammatory manifestations of the uterine cavity;
- inflammation of the ovaries and fallopian tubes;
- to relieve uterine tone.
Utrozhestan during pregnancy has limitations in use.
These manifestations include:
Effect on the body
The drug Utrozhestan has a different effect, depending on the period of admission: before becoming pregnant, or during the bearing of a child.
1. When planning a pregnancy:
2. Mechanism of action at gestational age up to 20 weeks:
- the drug must be applied vaginally, which relaxes the walls of the uterus;
- taking Utrozhestan has a positive effect on the nervous system due to a change in hormonal levels;
- reduces the threat of abortion;
- for safety net in case of spontaneous abortions in anamnesis;
- history of infertility;
- with nervous excitability;
- reduces the body's response to the manifestation of toxicosis;
- used for bloody discharge from the vagina, due to the threat of abortion - relieves spasm;
- relieves pain in the lower abdomen;
- relaxes the hardened uterus, as a result of the threat of termination of pregnancy;
- with fetal hypoxia;
- with the threat of abortion;
- relieves inflammation in the genitourinary system;
- restores the level of progesterone, which affects the termination of pregnancy;
- to support intrauterine development of the fetus until the placenta is formed.
3. Utrozhestan in late pregnancy:
Instructions for using candles
Utrozhestan (during pregnancy or when planning it) must be taken in the form of rounded tablets, the same as oral ones, but with a higher dosage - 0.2 g.
When planning pregnancy, suppositories should be used in the following pathological conditions:
- hormone replacement therapy in the absence of one of the two paired female genital organs - the ovary;
- in violation of the hormonal function of the paired organ;
- before IVF fertilization;
- in the absence of ovulation;
- with irregular ovulation, due to disruption of the endocrine glands;
- as preventive measures for spontaneous abortions due to endogenous insufficiency;
- threats of spontaneous abortions in history;
- treatment of uterine fibroids when planning pregnancy;
- treatment of early menopause when planning pregnancy;
- as a preventive method of treatment of growing connective tissue of the uterus when planning pregnancy.
Only a doctor deals with the treatment of pathological processes.
Dosages:
During pregnancy, Utrozhestan suppositories must be used in the following pathological conditions:
- with insufficient production of endogenous steroid;
- with hypoxia of the uterine layer;
- in violation of the blood circulation of the uterine cavity;
- with spontaneous bleeding;
- with premature detachment of the placenta;
- with increased tone of the muscular layer of the uterus;
- to increase the number of days of pregnancy - so that childbirth occurs on time;
- prevention of early delivery or miscarriage, which is already in the anamnesis;
- to improve blood circulation in the vessels of the muscular layer of the uterus and the child's place;
- for the prevention of fetal hypoxia;
- reduce the contractile activity of the uterine cavity;
- prevent untimely labor activity.
If a woman has a history of hormonal disorders, then the vaginal form of the drug Utrozhestan should be started immediately, from the moment of pregnancy.
Dosages:
The use of tablets
Utrozhestan for oral use is available in a dose of 0.1 g - 1 pc. Tablets must be taken when planning, as well as during pregnancy.
When planning pregnancy, Utrozhestan tablets should be used in the following pathological conditions:
- habitual spontaneous abortions;
- endogenous steroid infertility;
- problems with the uterine cavity;
- spontaneous abortions due to hormonal imbalance;
- pathological (genetic) insufficiency of endogenous steroid hormone;
- the absence of one paired female genital organ of the ovary;
Therapy should be prescribed only by the attending physician.
Application:
- Utrozhestan tablets when planning pregnancy should be taken from 0.2 g to 0.3 g per day - in the morning, afternoon and evening, 1 pc. at regular intervals. Do not chew. It is necessary to drink enough liquid. The duration of therapy with Utrozhestan tablets lasts from 10 to 14 days, you need to use the drug from the 14th day to the 26th day of menstruation. With the onset of pregnancy, the use of the drug Utrozhestan should be continued up to 14 weeks, and sometimes up to 28 weeks of pregnancy. The appointment and cancellation of the drug Utrozhestan occurs under the strict supervision of a physician.
During pregnancy, the tableted drug Utrozhestan must be started to be used in pathological conditions:
Treatment with Utrozhestan tablets should be carried out under the strict supervision of a physician.
Application:
- the usual amount of the drug - 0.2 g - 0.3 g per day - in the morning and in the evening, at regular intervals;
- IVF - Utrozhestan tablets must be taken before artificial insemination. It is necessary to take from 0.2 g to 0.6 g of the drug per day - 3 times in complex therapy with injections of pituitary hormones. The course of therapy with Utrozhestan tablets is 28 weeks from the moment of fertilization;
- with the threat of spontaneous abortion, tablets are prescribed from 0.2 g to 0.4 g per day, can be taken in 2-4 doses at regular intervals;
- in the prevention of spontaneous abortions in history - 0.2 g in the morning and evening. Treatment should be carried out before the 14th week of pregnancy if the pregnancy proceeds safely.
The correct use of the hormonal drug Utrozhestan during the carrying of a pathological pregnancy requires strict adherence to medical recommendations.
Tablets Utrozhestan:
- preventive measures for recurrent spontaneous abortions: it is necessary to use the drug within 14 weeks of pregnancy. If there is no positive result in the treatment, then the duration of therapy should be extended;
- in case of bleeding, it is necessary to use Utrozhestan tablets up to 24-28 weeks of pregnancy.
The tablet form of the drug Utrozhestan, in case of urgent need, can be used until the 38th week of pregnancy.
Candles Utrozhestan usually need to be prescribed up to 28 weeks. In case of urgent need, the use of the vaginal medication Utrozhestan should be extended until the 33-35th week of pregnancy.
Drug withdrawal scheme
If a woman used the drug Utrozhestan for 14 to 28 weeks of pregnancy, you need to smoothly and gradually reduce the dose of the drug.
For example: a pregnant woman consumes 0.4 g of the hormonal drug Utrozhestan per day, then in the next week the dose must be reduced by ¼. And so it is necessary to do every subsequent 7 days until the drug is completely discontinued.
Usually, doctors advise starting to reduce the dose of Utrozhestan no later than the 30th week of pregnancy, or even earlier. When the drug is discontinued, spotting usually appears, which should not be considered as a pathological process - the discharge will pass in a couple of days on its own.
The drug Utrozhestan, when planning pregnancy and its further bearing, as well as a drug for hormonal pathologies in women, has established itself as an effective remedy.
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