What happens from one tablet Goldline. Tablets Goldline as an effective means for weight loss: how to take and how harmful? What drugs should not be taken at the same time
A diet pill is not a dream, but a reality. There are a number of drugs that successfully help fight extra pounds. They are not only actively advertised, but also recommended by practicing nutritionists. One of the remedies that are used in the treatment of obesity is Goldline.
The pharmaceutical industry offers two types of diet pills - Goldline itself and the same one, but with the prefix "light".
In the first case, the remedy is used for severe obesity, when the body mass index is as high as possible, a person will have to get rid of 15 kg or more of excess weight.
But Goldline Light is, so to speak, a simplified version and is suitable for those people who have little excess weight (within 15 kg), they lose weight with mandatory physical activity and a strict diet.
The main active ingredient of the tablets is, which is included in the list of potent drugs and is dispensed in pharmacies strictly on prescription. But manufacturers added another active agent to Goldline Light - microcrystalline cellulose, and the drug was no longer prohibited for free sale.
The mechanism of action of sibutramineThe agent under consideration, regardless of its type, acts on the body in the same way: the main active substance, when it enters the human body, is converted into metabolites, which allows the capture of serotonin and norepinephrine. If you explain in "human" language, then everything can be reduced to three words: there is a loss of appetite. It is due to this that the intake of calories in the body decreases, adipose tissue begins to be actively consumed, and weight loss occurs.
Indications for the use of capsules
Goldline - capsules that are used only for medical reasons! Of course, you can buy pills online, but in this case, the actions of both the seller and the buyer fall under the article of the Criminal Code. And the thing is that in Europe and the USA the main active ingredient sibutramine is generally prohibited, and in Ukraine and the Russian Federation its free sale and purchase is considered a criminal offense.
Such strictness is due to the fact that many doctors and scientists compare the action of sibutramine with the action of amphetamines.
The indication for the use of capsules is a high body mass index (more than 30), in exceptional cases, the doctor may prescribe Goldline with a mass index of 27. The drug helps to stop the constant feeling of hunger, stop chronic overeating, which is a serious problem for obese people.
It should be noted right away that the drug in question is not a miracle and works only in combination with other measures aimed at weight loss. This wording refers to diet and exercise.
Contraindications and side effects
The drug is quite dangerous for some categories of patients. The official instructions for it indicate the following contraindications:
- neurological and mental disorders;
- diseases of the endocrine system;
- pathologies of the cardiac system, including unstable blood pressure;
- pregnancy and lactation period;
- angle-closure glaucoma.
In addition, there may be individual contraindications, which will be revealed by a dietitian after examining a patient with obesity.
Many patients who took Goldlight capsules noted a lot of side effects, they are also indicated as possible in the annotation to the drug:
- emotional disorders - mood instability, unreasonable irritation;
- headaches accompanied by nausea and vomiting;
- neurological disorders - insomnia, depression, anxiety, increased nervousness;
- backache;
- tachycardia;
- stomach ache.
Irritability
How to drink the drug
It is strongly not recommended to take Goldline on your own, side effects are always unpredictable. In addition to the appointment made by a nutritionist, he selects an effective dosage:
The capsule is consumed 5 minutes before breakfast or directly during breakfast. A prerequisite is to accompany the intake of a large amount of water drunk (at least 250 ml).
It is urgent to stop taking the drug in question if:
- increased heart rate up to 90 beats per minute and above;
- sudden increase in blood pressure;
- chest pain, difficulty breathing and tinnitus.
Interaction with other drugs
Doctors prefer not to prescribe other drugs at the same time as Goldline. This caution is due to the fact that the active substance of the tablets activates the processes of absorption in the body. Other drugs can, with such a rapid and complete entry into the bloodstream, cause a lot of side effects, including powerful poisoning of the body.
Nutritionists always warn that when treating obesity with Goldline, women should be especially careful to observe contraceptive measures and not plan pregnancy for another 6 months after the end of the intake.
Cost and points of sale
The price of Goldline diet pills is variable, but the average is 1300 rubles for 30 capsules. You can buy the drug only in the “light” version, but the standard one is sold in pharmacies, but only by prescription.
There are a lot of online pharmacies that will gladly sell Goldline capsules, but you need to take into account the danger of self-weight loss on them and the high probability of acquiring a fake.
Analogues of tablets Goldline Plus
The main active ingredient sibutramine is also found in Reduxin, Lindax and Meridia. All these drugs have the same mechanism of action on the body as the remedy in question. Therefore, analogues can be purchased only after the appointment of a dietitian, because they pose a health hazard.
Diet pills do not make it possible to get rid of extra pounds, sitting on the couch and eating them with a cake! Be sure to attend and regular physical activity, and correction of the diet. The drugs are designed only to speed up the process of splitting adipose tissue, and in combination, all this makes weight loss real even with severe obesity.
Useful video
About the effectiveness of the drug Goldline, see this video review:
Goldline is a drug made in India that helps to lose extra pounds through appetite suppression. This method of losing weight is recommended only for those people who suffer from obesity of the alimentary type of the first degree or higher. This disease is caused by lack of physical activity, improper diet, overeating, and not by metabolic disorders or pathologies.
Information about the drug
The drug Goldline is recognized as a potent weight loss agent. On the Internet, there are positive and negative reviews about Goldline diet pills. The negative ones are associated with a large number of side effects that the main active ingredient of the drug, sibutramine, causes. In many European countries, it is banned, and in Russia it is registered as a potent substance, so the weight loss drug Goldlight is not freely available. Doctors do not recommend drinking pills, because they consider sibutramine a drug, because its action is similar to that of cocaine.
On the territory of Russia, the slimming drug Goldline is not sold to everyone who wants to have a slender body, but only on the recommendation of a doctor to people with a mass index of 30 kg / sq.m. Therefore, diet pills that are sold on the Internet are probably contraband or fake, which means that taking them is either very dangerous for health or ineffective. Moreover, the effectiveness of the remedy is manifested in complex therapy with regular exercise and a strict diet.
Composition and mechanism of action of tablets
The Goldline weight loss drug contains sibutramine, which is an effective but dangerous substance, so the drug is listed as a potent drug. Once taken, the drug is converted by the body into active metabolites that prevent fat absorption. So, the action of the drug, in the first place, is aimed at suppressing appetite. For obese people, it helps to reduce the amount of food consumed and achieve a slim figure.
In addition to reducing appetite, the drug stimulates an increase in body temperature, due to which adipose tissue begins to break down more actively. The process of losing weight with Goldline is due to the action of metabolites that speed up metabolism and stimulate the formation of substances that tell the brain about satiety. So, the tool enhances the feeling of satiety and stimulates metabolic processes, due to which active weight loss occurs.
The mechanism of action of Goldline tablets on the human body is well understood. The effect of the drug is its effect on the cardiovascular system and the central nervous system. And although doctors' reviews of the Goldline weight loss drug are mostly negative, they sometimes prescribe a remedy for people to whom obesity is more harmful than taking sibutramine-based pills. They recommend using tablets only for those people who do not have poor tolerance to the components that make up the drug. The course of taking diet pills takes place under the supervision of a doctor who, if necessary, adjusts the therapy, maintaining a healthy state of the body losing weight.
How to take Goldline for weight loss: instructions
- The initial dosage is 10 mg per day. A doctor may lower it to 5 mg if a person does not tolerate treatment well. If within a month body weight has not decreased by 5% or more, the dose is increased to 15 mg.
- You need to drink diet pills on an empty stomach, washing down the capsules with plenty of water.
- Goldline should not be taken for longer than 2 years. Treatment is canceled if within 3 months the amount of weight lost has not reached 5% of body weight, therapy is canceled due to its ineffectiveness.
- The instruction to Goldline involves the simultaneous use of a weight loss product with physical activity and a balanced menu (refusal of fatty, salty, fried, sweet).
If you want to lose weight with Goldline, you will have to change your habits and lifestyle, the only way to maintain the results achieved after completing the course of taking the drug. Neglect of this rule is guaranteed to lead to re-gaining body weight.
Since the body's reactions to diet pills are individual and unpredictable, it is imperative to consult and examine a doctor before starting therapy. The specialist will tell you about the rules for taking the drug, possible side effects and prescribe a certain dosage.
Side effects
Reviews of losing weight in 2016 indicate the periodic manifestation of side effects while taking Goldline. They are expressed in the first 2 weeks of treatment, after their manifestation gradually decreases. Side effects of diet pills include:
- Nausea.
- Cardiopalmus.
- Sleep disorders, insomnia.
- Increased fatigue.
- Sweating.
- Irritation of the intestinal walls, which causes pain in the abdomen.
- Diarrhea or constipation.
- Dizziness, migraines.
- Mental disorders (unreasonable fear, panic).
- Swelling of the body.
- Violations of cerebral circulation (weak concentration of attention).
- Skin itching.
- Dry mouth.
In the presence of such signs, it is necessary to consult a doctor and, if necessary, stop taking the remedy.
Contraindications
Goldline is prescribed by a doctor only when other methods of losing weight have not brought results or have helped little in the fight against excess weight. Contraindications to the use of weight loss Goldline are:
- Pregnancy, lactation.
- Serious eating disorders (an attack of bulimia, anorexia).
- Hypertension.
- Individual intolerance.
- Diabetes.
- Nervous tics.
- Angle-closure glaucoma.
- Insufficiency or disease of the kidneys and liver.
- Age under 15 or over 65.
- Dependence on drugs/alcohol.
- Cholelithiasis.
- Pheochrotocytoma.
Use during pregnancy and lactation
There is no evidence that the pills are safe for the fetus, since there have not been enough studies, Goldline is not recommended for use during pregnancy. Doctors do not recommend drinking pills during lactation, because it is not known what effect the remedy will have on the child's body during breastfeeding. Women of childbearing age should use contraceptives when taking the drug for weight loss.
Interaction with drugs
Slimming capsules cannot be taken with many drugs in order to avoid side effects such as increased blood pressure, disruption of the brain, arrhythmia, convulsions, diarrhea, etc. It is forbidden to take Goldline simultaneously with:
- Other means for weight loss.
- Drugs acting on the central nervous system.
- Sleeping pills.
- MAO inhibitors (after completing the course of taking them, you should wait 2 weeks before taking diet pills).
- Means that stimulate the active production of serotonin.
Drug analogues
There are a variety of drugs that are effective analogues of Goldline capsules. They help treat obesity and are based on sibutramine. Structural analogues of Goldline capsules are:
- Lindax.
- Slimia.
- Sibutramine.
- Meridia.
Price in pharmacies
The weight loss product is produced by the Indian pharmaceutical company Ranbaxy. It is possible to buy Goldline in Russian pharmacies by prescription or by ordering online. The price of diet pills may vary from place to place.
Packaging on average costs 950-1000 rubles in pharmacies in Moscow for 30 capsules. It is possible to buy Goldline 15 mg in an online pharmacy with delivery in Russia at a price of 750 rubles for Goldline 15 mg caps. No. 30.
Doctors' opinion
There is no single opinion that all doctors would adhere to. There are two opinions:
- Some argue that diet pills are more dangerous than useful. They negatively affect the psyche and the work of the human heart. The proof of these beliefs is the fact that Goldline is banned in most countries.
- The second believe that there is no reason to refuse to use the remedy. Experience in the treatment of obesity shows that, following the correct dosage and recommendations of a doctor, Goldline can become an effective and safe method of treating obesity. Proof of this are the positive reviews of people who managed to get rid of excess weight with the help of pills and feel great.
In this article, you can read the instructions for using the drug Goldline. Reviews of site visitors - consumers of this medicine, as well as opinions of doctors of specialists on the use of Goldline in their practice are presented. A big request to actively add your reviews about the drug: did the medicine help or not help get rid of the disease, what complications and side effects were observed, perhaps not declared by the manufacturer in the annotation. Analogues of Goldline in the presence of existing structural analogues. Use for the treatment of obesity and weight loss in adults, children, as well as during pregnancy and lactation. The composition of the drug.
Goldline- a drug for the treatment of obesity of central action. Sibutramine (the active ingredient in Goldline) is a prodrug and exerts its effect through metabolites (primary and secondary amines) that inhibit the reuptake of monoamines (mainly serotonin and norepinephrine). An increase in the content of neurotransmitters in the synapses increases the activity of central serotonin 5HT receptors and adrenoreceptors, which contributes to an increase in satiety and a decrease in the need for food, as well as an increase in thermal production. Indirectly activating beta3-adrenergic receptors, sibutramine acts on brown adipose tissue.
Weight loss is accompanied by an increase in serum HDL concentration and a decrease in triglycerides, total cholesterol, LDL and uric acid.
Sibutramine and its metabolites do not affect the release of monoamines, do not inhibit MAO, do not have affinity for a large number of neurotransmitter receptors, including serotonin (5HT1-, 5HT1A-, 5HT1B-, 5HT2A-, 5HT2C-), adrenergic (beta1-, beta2-, beta3-, alpha1-, alpha2-), dopamine (D1-, D2-), muscarinic, histamine (H1-), benzodiazepine and NMDA receptors.
Compound
Sibutramine hydrochloride monohydrate + excipients.
Pharmacokinetics
After oral administration, it is rapidly absorbed from the gastrointestinal tract by at least 77%. During the "first pass" through the liver, it undergoes biotransformation under the influence of the cytochrome P450 3A4 isoenzyme with the formation of two active metabolites (mono- and didesmethylsibutramine). It is quickly distributed on fabrics. Active metabolites undergo hydroxylation and conjugation to form inactive metabolites, which are excreted primarily by the kidneys.
Indications
- alimentary obesity with a body mass index (BMI) of more than 30 kg/m2;
- alimentary obesity with a BMI of more than 27 kg/m2 in combination with type 2 diabetes mellitus or dyslipoproteinemia.
Release form
Capsules 10 mg and 15 mg (sometimes erroneously called tablets).
Instructions for use and dosing regimen
Goldline is prescribed orally 1 time per day. The dose is set individually, depending on tolerability and clinical efficacy. An initial dose of 10 mg is recommended, with poor tolerance, 5 mg may be taken. Capsules should be taken in the morning without chewing and with a sufficient amount of liquid (a glass of water). The drug can be taken on an empty stomach or combined with food intake. If a weight loss of 5% or more is not achieved within 4 weeks from the start of treatment, then the dose is increased to 15 mg per day.
Treatment with Goldline should not be continued for more than 3 months in patients who do not respond well enough to therapy, i.e. who within 3 months of treatment fail to achieve a 5% reduction in body weight from baseline. Treatment should not be continued if, during further therapy, after the achieved weight loss, the patient again adds 3 kg or more in body weight. The duration of treatment should not exceed 2 years, since there are no data on efficacy and safety for a longer period of taking sibutramine.
Goldline treatment should be carried out in conjunction with diet and exercise under the supervision of a physician with practical experience in the treatment of obesity.
Side effect
- insomnia;
- headache;
- dizziness;
- anxiety;
- paresthesia;
- tachycardia;
- heartbeat;
- increase in blood pressure;
- symptoms of vasodilation (including flushing of the skin);
- exacerbation of hemorrhoids;
- dry mouth;
- loss of appetite;
- constipation;
- nausea;
- taste change;
- increased sweating;
- dysmenorrhea;
- swelling;
- flu-like syndrome;
- skin itching;
- backache;
- paradoxical increase in appetite;
- thirst;
- rhinitis;
- depression;
- drowsiness;
- emotional lability;
- anxiety;
- irritability;
- nervousness;
- acute interstitial nephritis;
- bleeding;
- purpura of Shenlein-Genoch (hemorrhages in the skin);
- convulsions;
- thrombocytopenia.
Contraindications
- the presence of organic causes of obesity (for example, hypothyroidism);
- severe eating disorders (anorexia nervosa or bulimia nervosa);
- mental illness;
- Gilles de la Tourette syndrome (generalized tics);
- simultaneous reception of MAO inhibitors or their use within 2 weeks before the appointment of the drug Goldline;
- the use of other drugs acting on the central nervous system (for example, antidepressants, antipsychotics);
- the use of drugs prescribed for sleep disorders containing tryptophan, as well as other centrally acting drugs for weight loss;
- IHD, decompensated chronic heart failure, congenital heart defects, peripheral arterial occlusive diseases, tachycardia, arrhythmia, cerebrovascular diseases (stroke, transient cerebrovascular accident);
- uncontrolled arterial hypertension (BP above 145/90 mm Hg);
- thyrotoxicosis;
- severe violations of the liver and / or kidneys;
- benign prostatic hyperplasia;
- pheochromocytoma;
- angle-closure glaucoma;
- established pharmacological, drug or alcohol dependence;
- pregnancy;
- lactation period (breastfeeding);
- age up to 18 years and over 65 years;
- established hypersensitivity to sibutramine or to other components of the drug.
Use during pregnancy and lactation
Since there are still not enough convincing studies on the safety of sibutramine exposure to the fetus, this drug should not be used during pregnancy.
Goldline should not be taken while breastfeeding.
Women of childbearing age should use contraceptives while taking Goldline.
Use in elderly patients
Contraindicated in the elderly over the age of 65 years.
Use in children
Contraindicated in children under the age of 18 years.
special instructions
Goldline should be used only in cases where all non-drug measures to reduce body weight are ineffective, if the weight loss for 3 months was less than 5 kg.
Treatment with Goldline should be carried out as part of complex therapy for weight loss under the supervision of a physician with practical experience in the treatment of obesity. Comprehensive therapy includes both diet and lifestyle changes and increased physical activity. An important component of therapy is the creation of prerequisites for a stable change in dietary habits and lifestyle, which are necessary to maintain the achieved weight loss even after discontinuation of drug therapy. As part of therapy with Goldline, patients need to change their lifestyle and habits in such a way as to ensure that the achieved weight loss is maintained after treatment is completed. Patients should clearly understand that failure to comply with these requirements will lead to a repeated increase in body weight and repeated visits to the attending physician.
In patients taking Goldline, it is necessary to measure the level of blood pressure and heart rate. In the first 2 months of treatment, these parameters should be monitored every 2 weeks, and then monthly. In patients with arterial hypertension, in whom, against the background of antihypertensive therapy, the level of blood pressure is higher than 145/90 mm Hg. Art., this control should be carried out especially carefully and, if necessary, at shorter intervals. In patients in whom blood pressure twice exceeded the level of 145/90 mm Hg during repeated measurement. Art., treatment with Goldline should be suspended.
Particular attention should be paid to the simultaneous administration of drugs that increase the QT interval. These drugs include histamine H1 receptor blockers (astemizole, terfenadine), antiarrhythmic drugs that increase the QT interval (amiodarone, quinidine, flecainide, mexiletine, propafenone, sotalol), cisapride, pimozide, sertindole, and tricyclic antidepressants. This also applies to conditions that can lead to an increase in the QT interval, such as hypokalemia and hypomagnesemia.
The interval between taking MAO inhibitors and Goldline should be at least 2 weeks.
Although a relationship has not been established between taking Goldline and the development of primary pulmonary hypertension, however, given the well-known risk of drugs in this group, with regular medical monitoring, special attention should be paid to symptoms such as progressive dyspnea, chest pain and swelling in the legs.
If you miss a dose of Goldline, you should not take a double dose of the drug in the next dose, it is recommended to continue further taking the drug according to the prescribed scheme.
Duration of reception Goldline should not exceed 2 years.
Influence on the ability to drive vehicles and control mechanisms
Taking the drug Goldline may limit the ability to drive vehicles and control mechanisms.
drug interaction
Inhibitors of microsomal oxidation, incl. inhibitors of the CYP3A4 isoenzyme (ketoconazole, erythromycin, cyclosporine), increase plasma concentrations of sibutramine metabolites with an increase in heart rate and a clinically insignificant increase in the QT interval.
Rifampicin, macrolide antibiotics, phenytoin, carbamazepine, phenobarbital and dexamethasone can accelerate the metabolism of sibutramine.
The simultaneous use of several drugs that increase the content of serotonin in the blood can lead to the development of a serious interaction.
Serotonin syndrome can develop in rare cases when Goldline is used concomitantly with selective serotonin reuptake inhibitors (drugs used to treat depression), with certain drugs for the treatment of migraine (sumatriptan, dihydroergotamine), with opioid analgesics (pentazocine, pethidine, fentanyl) or antitussive drugs (dextromethorphan).
Goldline does not affect the effect of oral contraceptives.
Medicines that increase blood pressure or heart rate (ephedrine, phenylpropanolamine, pseudoephedrine, and combination medicines for the treatment of colds containing these drugs) increase the risk of increasing blood pressure and heart rate.
With the simultaneous administration of Goldline and alcohol, there was no increase in the negative effect of ethanol. However, alcohol is absolutely incompatible with the dietary measures recommended when taking sibutramine.
Analogues of the drug Goldline
Structural analogues for the active substance:
- Lindax;
- Meridia;
- Reduxin;
- Reduxin Light;
- Sibutramine;
- Slimia.
In the absence of analogues of the drug for the active substance, you can follow the links below to the diseases that the corresponding drug helps with and see the available analogues for the therapeutic effect.
Among the popular drugs that help to lose weight, Indian-made Goldline, which guarantees positive results in losing weight, enjoys special attention. Goldline diet pills are developed by Indian experts and include only natural-based ingredients. The action of the drug Goldline is to suppress the feeling of hunger, as well as the infringement of appetite, which is the effectiveness of its action.
When taking the drug Goldline, a satiety effect is created, which helps to avoid feelings of hunger and constant overeating. Many losing weight of all weight loss products prefer Goldline, due to its beneficial properties and natural composition. Goldine promises not only weight loss, but also an improvement in metabolic processes in the body, which will allow you to maintain optimal weight even after the drug is discontinued. The active substance contained in the Goldline tablets provides a guaranteed result in losing weight. Reviews of those who managed to achieve positive results in the struggle for an ideal figure note the successful disposal of 5-10 kg of excess weight in a relatively short period of time.
Today's popular pills called Goldline are included in the category of natural, harmless dietary supplements aimed at weight loss. According to the indication, these capsules will allow you to get positive results and reduce weight, correct the figure, while avoiding sagging skin. Despite the quick effect, taking Goldline tablets is not accompanied by addiction, after which the weight stops in place and weight loss becomes difficult. The composition of the drug contains not only active active ingredients that affect the process of losing weight, but also natural ingredients that affect metabolic processes and the absorption of vitamins by the body.
Please note: Goldline is not a magic tool that destroys body fat. This drug belongs to the category of aids for weight loss and has a significant impact on the process of losing weight only when dieting and playing sports.
The description of the drug Goldline indicates that it also has a noticeable effect on the functioning of the stomach, namely, it affects the metabolism, regulating it. Thus, the regular intake of capsules allows you to control the amount of carbohydrates that enter the body with food, to influence the process of deposition and breakdown of fats. Today, Goldline tablets of this company can be purchased at a pharmacy. Before taking, it is recommended to consult a doctor who can prescribe the best option for taking the remedy.
The composition of the tablets
Before you start taking diet pills, you must carefully study the composition of the drug Goldline and indications for use. One of the most important active ingredients in the composition of the capsules is the substance sibutramine, an enzyme that affects the manifestation of hunger. It is this enzyme that helps reduce appetite, suppresses hunger and allows you to significantly reduce the number of calories consumed per day.
However, despite the fact that the tablets contain sibutramine, which is a psychotropic substance, Goldlan does not belong to the category of harmful "dietary supplements".
This is a medicine that acts directly on the center of the brain responsible for the feeling of hunger and satiety, without causing addiction and without harming health.
Other components in the composition of Goldline tablets include:
- cellulose;
- lactose;
- silicon dioxide;
- magnesium stearate;
- hydrochloride monohydrate and others.
The form of release of the drug Goldline may vary. Today on sale you can find a drug that is produced in the form of capsules protected by a shell, which contain 15 mg of sibutramine. The number of capsules in a package is from 10 to 30 pieces, depending on the release. You can buy the drug at a pharmacy according to a prescription previously issued by a doctor. The purchase price of Goldline may vary depending on the number of capsules in the package and the form of release: from 700 to 900 rubles.
Expert opinion
Smirnov Viktor Petrovich
Nutritionist, Samara
At the same time, there are indeed serious indications for the use of sibutramine: this is alimentary obesity, in which the body mass index exceeds 30 without pathology from the endocrine system. Thus, it is not recommended to simply treat with Goldline or other tablets containing sibutramine. The action on the food center located in the brain does not always go unnoticed. There are numerous side effects - dry mouth, insomnia, constipation, headache. In addition, the effect of sibutramine weakens, and, starting from 2 or 3 packs, the effect weakens, and the person begins to independently increase the dose. This can lead to dangerous consequences. All drugs for weight loss should be prescribed only after the principles of a healthy diet, and then a diet with increased physical activity, have not led to the desired result.
The action of the remedy
According to the indications for taking Goldlan, the instructions for using the remedy state that it has a complex, central effect, according to the target direction. The main active substance sibutramine inhibits the production of mediators serotonin and norepinephrine in the brain, affecting their production.
An increase in the production of these substances in the brain affects the feeling of hunger, reduces appetite and promotes rapid satiety. This effect allows you to reduce the natural needs of the body for food, thereby contributing to its smaller consumption and weight loss.
This does not mean that a person limits the amount of food to a risky minimum. Just to feel comfortable and saturate the body with important elements, it needs less food. In addition, the sibutramine in Goldline also contributes to an increase in thermal production, which in turn leads to a large amount of calorie intake by the body.
The manufacturer also indicates that the Indian drug Goldline affects:
- metabolic processes in the body;
- general tone;
- affects the process of breakdown of adipose tissue;
- treatment of diabetes;
- treatment for diseases associated with the work of housing and communal services;
- normalization of the cardiovascular system.
It should be noted that taking Goldline is accompanied by an increase in body temperature. A similar effect helps to actively influence adipose tissue, affecting its splitting. However, in order to be effective in losing weight, it is necessary to strictly follow the indications for taking the tablets and refuse them if taking Goldline is contraindicated for you according to the instructions.
How to take Goldline
When deciding to use an additional tool for weight loss, it is necessary to study the instructions and indications for the use of Goldline in order to avoid unpleasant side effects. According to the instructions, the remedy should be taken one capsule per day.
Important! The initial dose of administration is 10 mg. Dosage can be reduced to 5 mg for side effects, dizziness, weakness, and increased to 15 mg to increase the effect. The maximum dose of 15 mg should be strictly prescribed by the attending physician.
It is recommended to take Goldline tablets in the morning on an empty stomach with a glass of pure non-carbonated water. The optimal course of using a weight loss product is from two weeks to a month. The course can be extended up to several months with a large excess weight. According to the reviews of those who are losing weight for the first course of taking this remedy, you can successfully overcome up to 10 kg of excess weight. However, if after the expiration of 3 months of treatment there are no positive results in losing weight, Goldline should be discontinued.
Who can take diet pills
According to the instructions, the Indian-made Gold Line is indicated exclusively for people suffering from excess weight. In this case, the best results will be in obese people. In order for the Goldline tool to give the desired result on the way to a slim figure, the total body weight must be 15-20 kg more than the norm. It is important to consider the cause of overweight.
Important! The drug will not be able to help get rid of a few extra pounds with a low initial weight, as it is indicated for use at different stages of obesity. In addition, the result of taking capsules is not guaranteed if the cause of overweight is heredity, genetic syndrome, diseases of the endocrine system, and not lifestyle and nutrition.
It should also be borne in mind that self-administration of pills can only harm the body and cause unwanted side effects caused by improper intake and dosing. The agent in Goldline capsules is prescribed by the attending physician, who will help determine the optimal dose and regimen for taking the drug.
Contraindications for use
Before you start taking an auxiliary drug, it is important to consider that Gold Line slimming capsules can cause negative consequences and may be contraindicated for use by some categories of people. This applies not only to people with initially low initial weight, adolescents under 18 years of age.
According to the description to the instructions, taking Goldline is contraindicated in:
- organic or genetic reasons for weight loss;
- bulimia and other nervous disorders;
- diseases of the heart and blood vessels;
- with circulatory disorders of the brain;
- prostate;
- glaucoma;
- adenoma;
- gastritis and ulcer;
- pregnancy;
- eating disorders;
- kidney diseases.
In addition, the drug Goldline is prohibited for use by pregnant women, people suffering from drug addiction and addiction, as well as with individual sensitivity to the composition of the drug. In case of violation of the recommendations for use, the use of the drug may be accompanied by some side effects: nausea, dizziness, excessive sweating, dry mouth, diarrhea, swelling, fatigue, and others. All negative consequences can be easily avoided with the correct dosage and intake of capsules.
According to numerous reviews on the Internet, Goldline capsules really help get rid of the hated kilograms when nothing can help. You can find a lot of good reviews about taking this remedy with accompanying before and after photos that encourage you to try the pills. However, it is important to consider that only a specialized doctor can prescribe capsules. Independent use of Goldline can be accompanied by negative consequences for the body and cause significant harm to your health.
Instructions for use:
Goldline Plus is a drug for the treatment of obesity. The composition of the drug includes sibutramine and microcrystalline cellulose. According to the content of sibutramine in one capsule, the drug is available in two dosages - 10 mg and 15 mg.
Goldline Plus is a combination drug. Sibutramine is a potent substance, however, in combination with microcrystalline cellulose, it does not belong to the list of potent drugs and is dispensed according to the 107 form prescription.
pharmachologic effect
Sibutramine and its metabolites affect the reuptake of neurotransmitters - serotonin and norepinephrine in the synaptic cleft, due to this, the feeling of satiety is prolonged (the feeling of hunger is dulled) and heat production is increased (thermogenesis increases). As a result of numerous clinical studies, it has been shown that while taking sibutramine, the amount of food consumed is reduced by 20%, and calories by 25%. At the same time, against the background of increased thermogenesis, about 100 kcal per day is additionally consumed.
With a decrease in body weight while taking Goldline Plus, there is an increase in high-density triglycerides (HDL) in the blood, a decrease in triglycerides, total cholesterol, low-density lipoprotein (LDL) and uric acid.
Sibutramine does not have a narcotic effect; when taking the drug, addiction does not develop.
Microcrystalline cellulose is an enterosorbent, has sorption properties and a nonspecific detoxification effect. It binds and removes from the body various microorganisms, their metabolic products, toxins of exogenous and endogenous nature, allergens, xenobiotics, as well as an excess of some metabolic products and metabolites responsible for the development of endogenous toxicosis.
Indications for use
Indications for the use of Goldline Plus are:
- Obesity with BMI (body mass index) more than 30 kg / m 2
- Overweight with a BMI of more than 27 kg / m 2 in the presence of concomitant diseases (hypertension, type 2 diabetes mellitus)
Dosage and administration
Goldline Plus is taken one capsule per day in the morning. Treatment begins with a lower dosage of 10 mg. If within 4 weeks of taking a weight loss of more than 2 kg is not achieved, they switch to a larger dosage - 15 mg.
The effect of the drug develops gradually during the first month, the maximum effect is observed after 3 months of continuous use. If you miss taking the drug, you should not take a double dose the next day.
It is recommended to take Goldline Plus in a course of 6 months, since during this time not only a significant reduction in body weight is achieved, but also the correct eating habits are formed. Due to this, the partial effect after discontinuation of the drug lasts up to 2 years. The maximum duration of administration should not exceed 1 year, since there are no data from clinical studies on the efficacy and safety of longer use.
Reception Goldline Plus should be discontinued if the patient responds poorly to therapy - if after three months of use, the decrease in body weight was less than 5%.
It should be remembered that Goldline Plus is used only in complex therapy along with hypocaloric nutrition and physical activity.
Side effects
Basically, side effects when taking Goldline Plus are observed during the first month of admission, they are not severe, do not require pharmacological correction and disappear on their own after a month.
The following side effects are mainly observed: dry mouth, insomnia, headache, dizziness, anxiety, increased heart rate, increased blood pressure, loss of appetite, constipation, nausea, increased sweating.
Contraindications
- Established hypersensitivity to sibutramine or to other components of the drug;
- The presence of organic causes of obesity (for example, hypothyroidism);
- Serious eating disorders - anorexia nervosa or bulimia nervosa;
- mental illness;
- Syndrome of Gilles de la Tourette (generalized tics);
- Concomitant use of MAO inhibitors (eg, phentermine, fenfluramine, dexfenfluramine, ethylamphetamine, ephedrine)
- Cardiovascular diseases (in history or at present): ischemic heart disease (myocardial infarction (MI), angina pectoris); chronic heart failure in the stage of decompensation, occlusive diseases of peripheral arteries, tachycardia, arrhythmia, cerebrovascular diseases (stroke, transient disorders of cerebral circulation);
- Uncontrolled hypertension (blood pressure (BP) is higher than
145/90 mm Hg) (see also section "Special Instructions"); - Angle-closure glaucoma;
- thyrotoxicosis;
- Severe violations of the liver and / or kidneys;
- Benign prostatic hyperplasia;
- Pheochromocytoma;
- Established pharmacological, drug or alcohol addiction;
- Pregnancy and the period of breastfeeding;
- Age under 18 and over 65.
Goldline Plus cannot be used during pregnancy and lactation, since there are no clinical data on the safety of the effect of sibutramine on the fetus and infant.
Overdose
There are limited data on drug overdose. Most often, tachycardia, dizziness, headache, and increased blood pressure are observed. There is no specific treatment or antidotes. In case of overdose, it is necessary to stop taking the drug for a while and notify your doctor about this.
Analogues
The complete analogue in composition is Reduksin.
Additional Information
According to the instructions, Goldline Plus should be taken if independent attempts to reduce weight did not bring a tangible result - if within three months the weight loss was less than 5 kg.
However, in some cases, doctors recommend starting treatment with a combination of diet and appetite suppressants, such as Goldline Plus, so that at the initial stage, food restrictions are tolerated by the patient and correct eating habits are initially formed.